Program
| Nov. 19 (Wed) | |
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9:00-
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Welcome address |
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9:10-10:16
Leukemia 1 |
Umut Sahin How PML nuclear bodies drive APL cure by the retinoic acid/arsenic combination Seishi Ogawa Integrated molecular analysis of adult T-cell leukemia/lymphomas Takuro Nakamura Modeling fusion gene-associated bone and soft tissue sarcoma |
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(Break)
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10:46-12:14
Replicaiton and Cell cycle |
Jean-Marie Blanchard From cell cycle control to cell invasion: cyclin A2 a novel mediator of extracellular cues Makoto Nakanishi How do cells determine whether or not to undergo senescence? Eric Julien Unraveling cell-cycle functions of the histone H4-K20 methylation pathway Malik Lutzmann Absence of the DNA helicases MCM8 or MCM9 causes general genomic instability but leads to specific myeloproliferative neoplasms in the knockout mice |
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(Lunch)
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13:00-14:58
Signaling in Cancer 1 |
Patric Mehien The dependence receptor notion: from a cell biology paradigm to alternative anti-cancer therapies Hideyuki Saya Regulation of cell differentiation by actin dynamics and its application in cancer treatment Keiichi I. Nakayama Deep and absolute quantification of human proteome unveils a global landscape of cancer metabolism Serge Roche How tyrosine kinases promote metastasis in human cancer |
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(Break)
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15:18-16:02
Signaling in Cancer 2 |
Yoshinori Murakami Involvement of CADM1 in apoptosis induction of detached epithelial cells as a new type of dependence receptor Jean-Paul Borg PDZ domain interactions: from in vitro to in vivo studies |
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(Break)
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16:22-17:28
Cancer and Chromatin |
Jean-Marc Egly TFIIH, CSA and CSB mutations specifically disturb several steps during transcription Hiroyuki Aburatani Chromatin remodeling complex gene mutations in cancer HIroyuki Seimiya G-quadruplex, a potential modifier of cancer behavior and a therapeutic target for glioma stem cells |
| 19:00- |
Reception |
| Nov. 20 (Thu) | |
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9:00-10:06
Leukemia 2 |
Toshio Kitamura MDS induced by ASXL1 mutations and its leukemic transformation by an additional SETBP1 mutation Jacques Ghysdael Non canonical Wnt/Fzd/Ca2+ signaling is critical to leukemic cell propagating activity in T-cell acute lymphoblastic leukemia (T-ALL) and resistance to chemotherapy Isabelle Plo Modeling myeloproliferative neoplasms to decipher the pathogenesis and find new therapies |
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(Break)
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10:26-11:54
Cancer and Infection |
Jun-ichiro Inoue Tropomodulin 1 expression driven by NF-κB enhances breast cancer growth Masanori Hatakeyama Protein tyrosine phosphatase SHP1 negatively regulates the oncogenic action of the Helicobacter pylori CagA protein Urszula Hibner HCV-driven paracrine signalling in hepatocellular carcinoma Masao Matsuoka HTLV-1 bZIP factor suppresses apoptosis through inhibition of FoxO3a |
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(Lunch)
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| 13:30-14:30 |
Poster Discussion |
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14:30-15:58
Chromatin and Epigenetics |
Giacomo Cavalli Genome regulation by Polycomb proteins and 3D chromosome folding Fuyuki Ishikawa How telomerase is recruited to telomeres in human cells Eric Gilson The extraordinary life of TRF2 at extratelomeric sites Robert Feil Role of enhancer and long non-coding RNAs in mammalian genomic imprinting |
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(Break)
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16:28-17:34
Signaling in Cancer 3 |
Shin Maeda Requirement of c-Jun N-terminal kinase in tumor microenvironment for effective expansion of pancreatic cancer in mice Masanobu Oshima Inflammatory responses in gastrointestinal tumor development and malignant progression Yegor S. Vassetzky Nuclear organization in lymphoid cells: implications for chromosomal translocations and gene regulation |
| 19:00- | Dinner at "Ganko Sushi" |
| Nov. 21 (Fri) | |
|---|---|
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9:00-10:28
Replication and Repair |
Philippe Pasero SAMHD1 processes stalled forks and promotes replication restart Fumio Hanaoka Differential roles of translesion synthesis polymerases eta and iota in UV-induced mutagenesis Christophe Cazaux DNA Polymerase Theta contributes to set up the replication timing program in human cells Michelle Debatisse Respective roles of replication and transcription in common fragile site instability |
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(Break)
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10:48-11:32
Signaling in Cancer 4 |
Shigeki Higashiyama CUL3-BTB complexes multiply regulate angiogenesis Annick Harel-Bellan RNA interference and gene expression in mammals |
| Concluding remarks | |
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(Lunch)
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| 17:00-18:30 |
Special Noh Stage |